The third novel of the galaxy-spanning Sun Eater series merges the best of space opera and epic fantasy, as Hadrian Marlowe continues down a path that can only end in fire. Hadrian and his Red Company have been serving the Empire in military engagements against the Cielcin, the vicious alien civilisation bent on humanity's destruction. And they've been successful: a cult-like fervour building around following a particularly impressive victory. but popularity comes as a price: an assassination attempt, triggered by those within the Imperial government who are scared of his rise to prominence. Now the Empire has turned dangerous, Hadrian and his crew leave to pursue his true interest: a search for a long-rumoured connection between the first Emperor and the Quiet, the ancient, seemingly long-dead race. And he will find the next key to unlocking their secrets in a massive library on a distant world. The coordinates for their origin planet. A planet that no longer holds life, but ...
This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the p...